50-02-2 MSDS - Dexamethasone
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Dexamethasone

Identification
Name Dexamethasone
CAS Registry Number 50-02-2
Synonyms 16alpha)-;16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-(11bet;16alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-2,20-dione;16-alpha-methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,2;16-alpha-Methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione;16-alpha-methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4-dien;16alpha-Methyl-9alpha-fluoro-11beta-17alpha-21-trihydroxypregna-1,4-diene-3,20-dione;16-alpha-methyl-9-alpha-fluoro-1-dehydrocortisol
Molecular Structure Dexamethasone   50-02-2
Molecular Formula C22H29FO5
Molecular Weight 392.46
mp: 262-264 ℃(lit.)
Hazard Codes: Details
Risk Statements: 43-40-36/37/38-20/21/22
Safety Statements: 36/37-45-36-26-22
Supplier
Lightchem Inc
Supply Precious metal catalyst
OLED Materials etc.
www.lightchem.com
 
Wiki & MSDS
50-02-2.pdf
Dexamethasone
Skeletal formula of dexamethasone
Ball-and-stick model of the dexamethasone molecule
Clinical data
AHFS/Drugs.com Monograph
MedlinePlus a682792
Pregnancy
category
  • AU: A
  • US: C (Risk not ruled out)
Routes of
administration
by mouth, IV, IM, SC and IO
ATC code
  • A01AC02 (WHO) C05AA09 (WHO), D07AB19 (WHO), D10AA03 (WHO), H02AB02 (WHO), R01AD03 (WHO), S01BA01 (WHO), S02BA06 (WHO), S03BA01 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability 80-90%
Protein binding 77%
Metabolism hepatic
Biological half-life 190 minutes
Excretion Urine (65%)
Identifiers
CAS Number
  • 50-02-2 YesY
PubChem CID
  • 5743
IUPHAR/BPS
  • 2768
DrugBank
  • DB01234 N
ChemSpider
  • 5541 YesY
UNII
  • 7S5I7G3JQL
KEGG
  • D00292 YesY
ChEBI
  • CHEBI:41879 YesY
ChEMBL
  • CHEMBL384467 YesY
PDB ligand
  • DEX (PDBe, RCSB PDB)
ECHA InfoCard 100.000.004
Chemical and physical data
Formula C22H29FO5
Molar mass 392.461 g/mol
3D model (Jmol)
  • Interactive image
Melting point 262 °C (504 °F)
 NYesY (what is this?)  (verify)

Dexamethasone is a type of corticosteroid medication.[1] It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, and along with antibiotics in tuberculosis.[1] In adrenocortical insufficiency, it should be used together with a medication that has greater mineralocorticoid effects such as fludrocortisone.[1] In preterm labor, it may be used to improve outcomes in the baby.[1] It may be taken by mouth, as an injection into a muscle, or intravenously.[1] The effects of dexamethasone are frequently seen within a day and last for about three days.[1]

The long-term use of dexamethasone may result in thrush, bone loss, cataracts, easy bruising, or muscle weakness.[1] It is pregnancy category C in the United States meaning use should be based on benefits being predicted to be greater than risks.[2] In Australia, it is class A, meaning it has been frequently used in pregnancy and not been found to cause problems to the baby.[3] It should not be taken when breastfeeding.[1] Dexamethasone has anti-inflammatory and immunosuppressant effects.[1]

Dexamethasone was first made in 1957.[4] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] Dexamethasone is not expensive.[6] In the United States a month of medication typically costs less than 25 USD.[1] In India a course of treatment for preterm labor is about 0.5 USD.[6] It is available in most areas of the world.[6]


 







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